When we receive your urine sample, the first step is to prepare it for measurement in our laboratory. The prepared sample is then analyzed using CE-MS technology (capillary electrophore mass spectrometry). The resulting measurement data is processed in further processes so that they can be compared with the algorithm of a respective disease-specific protein pattern. Finally, the results of the individual xken components are used to create a complete report that is sent to your doctor.

The information carriers in the blood are broken down by enzymes shortly after collection. The amount of information contained in the blood depends largely on how quickly it was processed. This process is difficult to control. Urine, on the other hand, is very stable as a carrier of information. When the urine leaves the bladder, the enzymes' breakdown processes have already been completed. Therefore, your urine sample can also be transported uncooled in a urine tube with a stabilizer.

Analyzing your sample with xken enables a holistic view of your health at the molecular level. In this way, diseases can be detected as early as possible and treated individually with targeted therapy. At this stage, the disease can still be stopped before the first symptoms become apparent and manifest themselves in the form of organ damage. The diagnostic analysis is based on the measured proteins. For classic imaging methods, a significant abnormality must already be present at the cellular level in order to be diagnosable.

All individual xken health components have a CE declaration of conformity and comply with the Medical Devices Act (MPG) and the EU Directive 98/79/EC on in-vitro diagnostic devices (IVD).

The technology is based on the coupling of two established measurement methods: capillary electrophoresis and mass spectrometry. The proteins are first separated in an electrical field (25,000 volts) and then analyzed with a mass spectrometer. The data obtained in this way is evaluated using specially developed software and stored in our database. In the next step, complex statistical methods are used to identify disease-specific proteins (biomarkers) from the data. The recorded biomarkers are summarized using artificial intelligence and therefore achieve a level of accuracy that was previously not possible with individual biomarkers.

Biological age describes your physical condition. Scientists have proven that external influences, such as our living environment or habits, make us age faster or slower. Therefore, biological age cannot be equated with chronological age, which results from the date of birth.

The accuracy of the xken health components is between 85-95%.

Proteome analysis is a branch of biochemistry and analyzes all of the proteins in the body. (proteome). Proteins are the functional molecules of a cell and represent the basis of life. The proteome is dynamic and changes over time. It's different with genes, they always remain constant. The proteome therefore always represents the current state of the body (“snapshot”). The application-oriented clinical proteome analysis enables the implementation of the findings from basic research through to clinical studies, taking clinical needs into account. The mosaiques group has developed recommendations for clinical proteome analysis that have now become the standard in industry and research. Today the technology can be used successfully for both clinical diagnostics and the identification of therapeutic targets.

With clinical proteome analysis, all proteins in the human body can be analyzed. Knowledge of proteins (as biomarkers) enables a new level of disease understanding. This knowledge is the basis for prevention, diagnostics and therapy tailored to the individual needs of the patient, because every protein is a potential target for modern therapy. Clinical proteome analysis achieves a level of resolution that cannot be achieved with other clinical analysis methods. All measurements are carried out at the molecular level of the proteins (proteome). The high information density of these measurements shows a precise picture of the overall condition of the body. Every disease begins with changes in proteins, the cells’ function carriers. In contrast to genes that indicate a potential risk, the change in the proteome reflects the specific state of health or disease. These new possibilities of biomarker analysis open up previously unknown personalized and individualized therapeutic approaches for patients.

Diseases arise at the molecular level (= proteins) of the body. The biochemical processes involved in the development of diseases and their treatment take place at this level. Diseases are usually caused by changes not to a single protein, but to several proteins. The most comprehensive quantitative and qualitative assessment of proteins is necessary in order to precisely describe and treat diseases. The current condition of the body is particularly important. This is described by its proteins. This protein level remains closed to other “omics” technologies and can only be deciphered through proteome analysis.

Negative influences can lead to inflammatory processes in your body. Especially if they take place over a longer period of time. This chronic inflammation is now considered one of the main causes of cancer. OncoRisk can detect these inflammatory processes, which if left untreated can subsequently lead to cancer.

Regardless of your test results, xken health should be repeated at regular intervals. This way you can check whether you are still healthy or whether the therapies suggested by your doctor are having an effect.